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If Kafka had been a woman he would probably not have felt a need to make Gregor turn into a bug. Had Kafka been a woman who had ever been pregnant, it would have sufficed to simply let Gregor become oh let's say 7 months pregnant overnight to scare the shit out of him.  Of course, this would have had to led to an entirely different story, but the again perhaps not. Gregor's family may just have treated him the same were he suddenly to wake up highly pregnant one morning and the story could just have ended up the same.

The original title of the Metamorphosis is die Verwandlung, which is my opinion sounds much more omnious and dark. Apparently Kafka was very adamant that the book cover not show or in any way reflect the insect. 

Gregor Samsa is said to be based upon Kafka himself. As when Kafka suffered from insomnia and often feared he was repulsive and a burden to his family. His sister was his caretaker in real life and his father was not a very nice or caring man, both reflected in the novella from 1915.